Key Factors for Good Film Coating
::
Trouble Shooting During Film Coating
::
Sample Requirement Form
PROBLEMS
PROBABLE CAUSE
REMEDIES
Film Chipping
Low film strength
Increase film former concentration
Inadequate plasticizer
Increase plasticizer concentration
High pan rpm
Reduce pan rpm
Low spray rate
Increase spray rate Dilute Coating suspension
Very sharpTablet edges
Redesign Tablet Tooling
Film Peeling
Very high spray rate
Reduce spray rate
Low dry air temp.
Increase temp.
Tacky films
Add / increase anti adherants
Lack of adhesion toTablet surface
Add / include fillers like MCC or HPC in Tablet cores.
Orange Peel Appearance
Spray drying
Increase solvents
Fast drying rate
Reduce air atom pressure and readjust spray distance
High atomisation pressure
Reduce Qty / or temp.of dry air Reduce atomisation pressure
Bridging (Across Logos, Wedges, Break lines etc)
High spray rate coupled with equally and fast drying
Control spray rate and drying rate (This will be indicated by a lowering of Tablet bed temp.)
Deep wedges on Tablets
Redesign tablet tooling to avoid this.
Twinning
High Spray Rate (Over Wetting)
Controlled Spray Rate
Inefficient Drying system
Drying Capacity as per Spray Rate
Shape of Tablet
Avoiding Flat Surfaces